Benfica favourite here, I don't think so, for many reasons. First reasons is the fast pace and quality that Frankfurt has on the attack, Benfica hates to play against this type of teams, I remember Tondela giving them big problems that way and if Tondela had an Jovic, Rebic or Kostic things would have been really bad for Benfica in that day and having Gabriel injured for the rest of the season is also a big blow for this match-up in particular. The other reason is that Benfica big goal is to become League Champion once again, Coach Lage has rotated a bit in the Europa League and wouldn't be surprised to see it happen here again, for the club and for the Benfica fans this elimination doesn't matter much, they just wanna be "Campeão da Liga Portuguesa" again. About Frankfurt, personally I really like how this team plays football and if we take Bayern Munchen out of the Bundesliga, Frankfurt is in my opinion right now playing the best football in Germany, they also haven't lost a game since the year began and are on a nice 5 win streak but most important is how they are playing, high confidence football and with that mid-field and attack connecting so well together they will give Benfica a hard time and of course, not only they are making a great season in the Bundesliga but they have been amazing in the Europa League too, 8 wins and 2 draws and they played against some good teams, like Lazio and Marseille in the groupo stage and then eliminated S.Donesk and Inter Milan. I see Benfica scoring here at max 1 goal and on the other side I see Frankfurt scoring here at least 1 goal, like this line here.